Drugs are well-known causes of eosinophilic lung disease and patients with drug-induced eosinophilic lung disease can have variable clinical presentations. Clinical features may range from asymptomatic eosinophilic infiltrates to acute eosinophilic pneumonia (AEP)-like syndrome leading to acute respiratory failure. This report describes the first case of clomipramine-induced AEP-like syndrome causing acute hypoxemic respiratory failure which was treated successfully. Considering the increasing usage of tricyclic antidepressants, physicians should be aware of this very rare and life-threatening complication of clomipramine. [Anadolu Psikiyatri Derg 2016; 17(0.300): 27-30]